NMR metabolic profiling of Aspergillus nidulans to monitor drug and protein activity.

نویسندگان

  • Paxton Forgue
  • Steven Halouska
  • Mark Werth
  • Kaimei Xu
  • Steve Harris
  • Robert Powers
چکیده

We describe a general protocol for using comparative NMR metabolomics data to infer in vivo efficacy, specificity and toxicity of chemical leads within a drug discovery program. The methodology is demonstrated using Aspergillus nidulans to monitor the activity of urate oxidase and orotidine-5'-phosphate decarboxylase and the impact of 8-azaxanthine, an inhibitor of urate oxidase. 8-azaxanthine is shown to inhibit A. nidulans hyphal growth by in vivo inactivation of urate oxidase.

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عنوان ژورنال:
  • Journal of proteome research

دوره 5 8  شماره 

صفحات  -

تاریخ انتشار 2006